T cell receptor specificity for major histocompatibility complex proteins
نویسندگان
چکیده
منابع مشابه
T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions*
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3). TCR ligands compose a presentation platform (major histocompatibility complex (MHC)) and a variable antigenic component consisting of a short "foreign" peptide. The sequence of events when the TCR engages its peptide-...
متن کاملSpecificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products
We have analyzed a panel of T cell clones that corecognize defined epitopes of the insulin molecule in association with Ia for their patterns of recognition of alloantigens. A striking correlation is observed between recognition of the I-Ab gene product and cow insulin alpha loop and recognition of I-Eu of the PL/J haplotype. These results are consistent with the notion that reactions to foreig...
متن کاملT cell clones with dual specificity for M1s and various major histocompatibility complex determinants
A high proportion of T cell clones derived from bulk cultures selected to M1s a,d determinants were found to have joint specificity for allo-H-2 determinants, and vice versa. Significantly, the patterns of H-2 alloreactivity shown by clones selected to M1sa,b determinants appeared to be random. The possible implications of these findings are discussed.
متن کاملStructure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here we examine alloreactive TCR-gamma/delta T cell lines and clones that recognize MHC-encoded antigens. A BALB/c nu/nu (H-2d)-derived H-2k specif...
متن کاملSTRUCTURE AND SPECIFICITY OF T CELL RECEPTOR y/8 ON MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN-SPECIFIC CD3+, CD4-, CD8- T LYMPHOCYTES
Most antigen-specific peripheral murine Tlymphocytes express the Tcell differentiation antigens, CD4 or CD8, and a TCRcomposed ofa CD3-associated disulfidelinked heterodimer, TCR-a/(3 (1, 2) . However, recent studies have identified a distinct population of CD3+,CD4-,CD8cells that appear early in thymic ontogeny and are maintained in the mature thymus and the peripheral lymphoid organs througho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2008
ISSN: 0952-7915
DOI: 10.1016/j.coi.2008.03.008